Sign Up!
Login

Welcome to Surgical Pathology Atlas
Monday, February 06 2012 @ 06:42 PM CST

Benign vs Malignant repost

Ok since I have lost this article I will go ahead and repost it.


I split the cytologic criteria in 2 major groups.

I. Low power features:

  1. Necrosis ( careful with infections, foreign bodies, diabetes and RA)
  2. Increased celularity
  3. Unusual background substances ( mucin, colloid or keratin to name few)
  4. 3 dimensional celular architecture. This feature is good for epithelial malignancies which express surface adhesion molecules EpCAM

II. High power features:

  1. Increased celularity composed of s single cell clone
  2. Increased N:C ratios
  3. Nuclear membrane irregularities
  4. Prominent, irregular "Cherri red" nucleoli. Especially if nucleoli are as big as a mature lymphocyte
  5. Individual cell apoptosis
  6. Abnormal mitoses as well as increased number of mitoses
  7. Increased vascularity ( look for small capillaries)
  8. Evidence of desmoplasia or invasion if large tissue fragments are present.
  9. Necrosis ( demonstrated by nuclear dust)
  10. 3D clusters as above
  11. Nuclear margination ( nucleus is touching the cellular membrane)
  12. Effaced cellular polarity. If not effaced then we call it "school of fish" which is feature of a reactive process.
  13. Nuclear hyperchromasia ("pitch dark" nuclei like in squamous cell carcinoma or urotelial carcinomas)

Trackback

Trackback URL for this entry: http://www.surgicalpathologyatlas.com/glfusion/trackback.php/2008091521370750

No trackback comments for this entry.

5 comments

The following comments are owned by whomever posted them. This site is not responsible for what they say.
Authored by: Anonymous on Thursday, November 05 2009 @ 07:31 AM CST Benign vs Malignant repost

According to some thesis that a benign tumor is a tumor that lacks all three of the malignant properties of a cancer. Thus, by definition, a benign tumor does not grow in an unlimited, aggressive manner, does not invade surrounding tissues, and does not metastasize. Common examples of benign tumors include moles and uterine fibroids.

The term "benign" implies a mild and nonprogressive disease, and indeed, many kinds of benign tumors are harmless to the health. However, some neoplasms which are defined as 'benign tumors' because they lack the invasive properties of a cancer, may still produce negative health effects. Examples of this include tumors which produce a "mass effect" (compression of vital organs such as blood vessels), or "functional" tumors of endocrine tissues, which may overproduce certain hormones (examples include thyroid adenomas, adrenocortical adenomas, and pituitary adenomas).

Benign tumors typically are encapsulated, which inhibits their ability to behave in a malignant manner. Nonetheless, many types of benign tumors have the potential to become malignant and some types, such as teratoma, are notorious for this.

  • essay - Authored by: custom writing on Tuesday, July 05 2011 @ 04:38 AM CDT
Authored by: Anonymous User on Wednesday, April 06 2011 @ 02:44 AM CDT Benign vs Malignant repost
We need to learn more about how our body works. I've learned anatomy during my student years and it was fun. Frank @ Student Loans
Authored by: Anonymous User on Sunday, April 10 2011 @ 11:51 PM CDT Benign vs Malignant repost
Make yourself familiar with the latest celebrity hairstyles 2011 and follow the trend on what's hip and what's in.
Authored by: Anonymous User on Tuesday, June 07 2011 @ 08:38 AM CDT Benign vs Malignant repost
Your readers must love what you're writing based on their comments. Great topics really! Short Hairstyles

Google Links

Support the site by clicking on a link. If you are using AdBlock Plus please add site filter to allow Google AdSense:

Topics

My Account





Sign up as a New User
Lost your password?

Events

There are no upcoming events

Older Stories

Friday 03-Dec


Monday 25-Jan


Thursday 07-Jan