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Thursday, September 09 2010 @ 11:14 PM CDT

Head and Neck
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Juvenile nasopharyngeal angiofibroma (JNA) is a histologically benign yet locally aggressive vascular head and neck tumor. JNA affects almost exclusively adolescent boys, but has been reported in women and elderly patients on rare occasions. JNA is an uncommon tumor, with reported incidence between 1 in 5000 and 1 in 60,000 otolaryngology patients. It is estimated to account for only 0.5% of all head and neck neoplasms, but is nevertheless considered the most common benign neoplasm of the nasopharynx. Grossly, the JNA is a lobulated, firm, non-encapsulated mass, usually pink-gray or purple-red. The tumor base may be sessile or pedunculated, but the tumor often has numerous secondary attachments, complicating resection in continuity. Microscopically, the tumor is composed of thin-walled vessels of varying caliber in a mature connective tissue stroma. The vessels typically have a single endothelial cell lining without a muscularis layer, which probably explains the tumor's propensity for hemorrhage. Hystology: many blood vessels in fibrous stroma. DDX: Lobular capillary hemangioma (pyogenic granuloma)
Juvenile Nasopharyngeal Angiofibroma
Tuesday, December 01 2009 @ 12:25 PM CST
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Encapsulated or well-circumscribed neoplasm; Basal cell type proliferation with tubular growth with cuboidal to columnar cells with uniform hyperchromatic nuclei. Vascular stroma set distinctly against tubules. PAS positive diastase-sensitive granules. Differential Diagnosis: pleomorphic adenoma; ameloblastoma; Cutaneous basal cell carcinoma; Adenoid cystic carcinoma.
Canalicular Adenoma
Thursday, April 30 2009 @ 12:22 PM CDT
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* Trabecular arrangement * Dense fibrous bands (not shown above) * Spindled cells * Increased mitotic counts * Capsular invasion Immunohistochemistry: Ki-67 is high in carcinoma Cyclin D1 positive in carcinoma (>90%) but not in adenoma(
Parathyroid Carcinoma
Saturday, August 02 2008 @ 05:02 PM CDT
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Medullary carcinoma of the thyroid (MTC) is a distinct thyroid carcinoma that originates in the parafollicular C cells of the thyroid gland. These C cells produce calcitonin. MTC has a genetic association with multiple endocrine neoplasia (MEN) type 2A a
Medullary Carcinoma
Saturday, August 02 2008 @ 05:02 PM CDT
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Tumors are poorly defined, fleshy masses with areas of necrosis and hemorrhage. Microscopically they are composed of anaplastic cells with marked cytologic atypia and high mitotic activity. Tumor necrosis and vascular invasion are common. Histologic patte
Anaplastic Thyroid Carcinoma
Saturday, August 02 2008 @ 05:02 PM CDT
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Follicular Carcinoma, Insular Variant
Saturday, August 02 2008 @ 05:02 PM CDT
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Acinic Cell Carcinoma is a slow-growing malignant tumor, normally developing in the parotid glands and the major and minor salivary glands, upper lip, buccal mucosa, and the palate; and more rarely, in the parapharyngeal space, sublingual gland, pancrea
Acinic Cell Carcinoma
Saturday, August 02 2008 @ 05:02 PM CDT
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The essential lesion of Graves' disease is parenchymatous hypertrophy and hyperplasia, with tall cells, small follicles, scant and "scalloped" colloid, varying size and shape of the follicles, with columnar cells and reduced homogeneous colloid. Between t
Grave's Disease
Saturday, August 02 2008 @ 05:02 PM CDT
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Tall cell variant (TCV) is an aggressive form of papillary thyroid carcinoma (PTC), usually associated with higher local recurrence and distant metastasis. The cells are arranged around well-developed papillae. The height of the cells is at least twice t
Papillary Thyroid Carcinoma Tall Cell Variant
Saturday, August 02 2008 @ 05:02 PM CDT
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Polymorphous low-grade adenocarcinoma is a recently recognized salivary gland carcinoma arising primarily within the oral cavity. Most of these tumors are readily diagnosed; occasionally, however, they may be confused histologically with cellular mixed tu
Polymorphous Low-grade Adenocarcinoma
Saturday, August 02 2008 @ 05:02 PM CDT
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Hyalinizing trabecular neoplasm (HTN) of the thyroid gland was originally described as “an uncommon but potentially confusing neoplasm” by Carney and colleagues1 in 1987. HTN typically occurs in females as either a single dominant nodule or as part of a multinodular goiter. Several cases have occurred in association with Hashimoto's thyroiditis and prior neck irradiation.2 Grossly, HTN is a small (usually
Hyalinizing Trabecular Adenoma
Saturday, August 02 2008 @ 05:02 PM CDT
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Described by Wenig and Heffner (Ann Otol Rhinol Laryngol 1995;104:639). Histology: Respiratory epithelial adenomatoid hamartoma is an uncommon lesion that usually presents as a nasal or, infrequently, as a sinus or nasopharyngeal mass. In the largest series to date (31 cases), REAH was defined as an excessive proliferation of glandular respiratory epithelium and therefore considered to be a hamartoma.1 Morphologically, it is composed of respiratory-lined glands surrounded by a thickened and hyalinized basement membrane, often accompanied by an inflammatory background. Although there are characteristic histologic and immunophenotypic features that distinguish between REAH, IP, ITAC, and non-ITAC,2 the differential diagnosis can be challenging on small or fragmented endoscopic biopsies.
Respiratory Epithelial Adenomatoid Hamartoma
Saturday, August 02 2008 @ 05:02 PM CDT
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