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Thursday, September 09 2010 @ 11:21 PM CDT

Gastrointestinal system
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Undifferentiated gastric carcinoma with lymphoid stroma is a histological type of gastric cancer with favorable prognosis, microscopically characterized by nests of high grade neoplastic epithelial cells intermingled with a dense lymphoid proliferation. These are usually positve for EBV .
Undifferentiated lymphoepithelioma-like gastric carcinoma (Medullary carcinoma of stomach)
Tuesday, March 02 2010 @ 07:44 AM CST
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Alpha 1-antitrypsin deficiency (?1-antitrypsin deficiency, A1AD or simply Alpha-1) is a genetic disorder caused by defective production of alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. Lecture: http://www.youtube.com/watch?v=YxB04tGvqd0
Alpha-1-antitrypsin deficiency
Friday, November 13 2009 @ 09:24 AM CST
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Solid-pseudopapillary tumors of the pancreas (SPTs) are uncommon tumors, constituting only 1% of pancreatic neoplasms. SPTs are neoplasms of young women and are frequently grossly sharply circumscribed and cystic lesions (although their microscopic margins may be indistinct). Most importantly, despite their often large size (mean of >10 cm at presentation in one study), the vast majority of SPTs are indolent neoplasms. The neoplastic epithelial cells are uniform, polygonal, and discohesive in nature. Frequent degenerative changes in larger tumors, however, lend a characteristic pseudopapillary pattern because of residual epithelial cells that form perivascular rosettes. SPTs are known to consistently express vimentin, a-1-anti-trypsin, neuron-specific enolase, progesterone receptors, and more recently, CD10.
Solid Pseudopapillary Neoplasm of the Pancreas
Friday, November 13 2009 @ 09:18 AM CST
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These pancreatic tumors exhibit acinar differentiation and comprising less than 2% of these neoplasms. The overall survival is very poor with a medial survival approximately 16 to 20 months. ACC may arise in any portion of the pancreas. Most are large with approximate size of 10 cm in diameter. The acinar pattern shows multiple lumina with basally located nuclei and moderate amounts of eosinophilic granular apical cytoplasm. The solid pattern if present lacks lumen formation but may show basal palisading of the nuclei interface of the solid nests within the stroma. Occasionally cystic change and nodule nodular growth pattern and intraductal growth has been documented. The nuclei are relatively uniform oval with a central single nucleolus. There are easily detectable numerous mitotic figures. Zymogen cytoplasmic granules are positive on PAS stain and are resistant to diastase digestion. Immunohistochemical stains for the enzymes tripsin and chimotrypsin are very sensitive in detecting acinar differentiation. Differential diagnosis includes pancreatic endocrine tumors, pancreatoblastoma or solid papillary neoplasm as well also well differentiated adenocarcinoma.
Acinar Cell Carcinoma of the Pancreas
Friday, November 13 2009 @ 09:10 AM CST
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CCS is a rare disorder that was originally described by Leonard Wolsey Cronkhite Jr., an internist, and Wilma Jeanne Canada, a radiologist, in 1955. The syndrome is characterized by abnormalities of the gastrointestinal mucosal surfaces and the skin, together with clinical features of severe protein-losing malnutrition, gastrointestinal blood loss and the secondary effects of these. GI Tract: The stomach and colon are the most commonly involved sites, as well as the duodenum and distal ileum. The mucosal abnormalities are caused by expansions of the lamina propria, primarily be edema, but also inflammatory cells and macrophages. The epithelium is distorted and pits or crypts are cystically dilated. This expanded lamina propria may form polyps or nodular elevations, or may result in diffusely enlarged gastric or intestinal folds. To some, these polyps resemble juvenile polyps, and this disorder has been grouped with the hamartomatous polyposis syndromes Skin: Alopecia involving scalp, eyebrows, face and eventually complete hair loss is some patients. Onychodystrophic changes include thinning, splitting, onycholysis (partial separation of nail from bed), and onychomadesis (loss of finger and toenails). Hyperpigmentation in the form of pigmented macules and plaques on the hands and arms and elsewhere is the third cutaneous abnormality that may be seen. About 75% of the reported affected patients are Japanese, and the remainder European or North American. There are no know familial occurrences, and the etiology is not known.
Cronkhite-Canada Syndrome
Friday, May 08 2009 @ 03:17 PM CDT
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Peritoneal mesothelioma is a rare disease. The incidence is approximately one per 1,000,000 and about one fifth to one third of all mesotheliomas are peritoneal.The architectural features of the peritoneal mesothelioma may be quite heterogeneous including
Peritoneal Mesothelioma
Saturday, August 02 2008 @ 05:08 PM CDT
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Enzinger FM, Weiss SW (Soft tissue tumour, 2nd ed 1988: 533-544) described hemangioendotheliomas as vascular tumours of intermediate, borderline or low grade malignancy. The term "hemangioendothelioma" has been used to designate various groups of vascular tumours. Some of these entities are benign non- neoplastic reactive lesions. Bening: Benign infantile hemangioendothelioma Masson's vegetant intravascular hemangioendothelioma Spindle cell hemangioendothelioma/hemangioma Kaposiform hemangioendothelioma Low grade (borderline): Retiform hemangioendothelioma Polymorphous hemangioendothelioma Composite hemangioendothelioma Dabska's tumor. Malignant: Epithelioid hemangioendothelioma Location: Soft tissue, lung, pleura, liver, peritoneum, bone, lymph nodes and skin. Age: Middle-aged adults. EH is a poorly defined and infiltrative tumour, characterized by nests and cords of spindle to epithelioid cells embedded in a hyaline, myxoid, chondroid or collagenous stroma. The cells show prominent cytoplasmic vacuoles. Red blood cells may be present within some of these vacuoles (reminiscent of primitive vascular channels). These vacuoles are mucin negative. There may be abundant osteoclast-like giant cells ; dystrophic calcification; metaplastic ossification. There is a low mitotic activity and mild to moderate pleomorphism. Immuno: CD31+, VIII+ and focally for (CK7, CK8, CK18)+
Epitheloid Hemangioendothelioma
Saturday, August 02 2008 @ 05:08 PM CDT
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The adults live in the host's large intestine with their anterior ends embedded in the cells that line the intestine; each female can produce in excess of 10,000 eggs/day. Most infections of whipworms are probably asymptomatic. However, because the worm
Trichuris Trichiura
Saturday, August 02 2008 @ 05:08 PM CDT
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Whipple disease is a systemic disease most likely caused by a gram-positive bacterium, Tropheryma whippelii. Although the first descriptions of the disorder described a malabsorption syndrome with small intestine involvement, the disease also affects the
Whipple Disease
Saturday, August 02 2008 @ 05:08 PM CDT
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CMV Gastritis
Saturday, August 02 2008 @ 05:08 PM CDT
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Gallbladder carcinoma, a highly lethal condition, is the sixth most common gastrointestinal malignancy (after colon, pancreas, stomach, liver, and esophagus). Because symptoms are often vague, this carcinoma is frequently detected late; in fact, detection
Adenocarcinoma of the Gallbladder
Saturday, August 02 2008 @ 05:08 PM CDT
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Gastrointestinal stromal tumours (GIST) constitute a broad spectrum of nonepithelial neoplasms arising from connective tissue elements located along the entire length of the gastrointestinal wall. They are rare neoplasms which account for 0.1-1% of gastro
Malignant Gastrointestinal Stromal Tumor
Saturday, August 02 2008 @ 05:08 PM CDT
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