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Thursday, September 09 2010 @ 10:27 PM CDT

Breast
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Breast lesion composed of intralumenal clusters of spherules http://surgpathcriteria.stanford.edu/breast/collspher/
Collagenous Spherulosis
Wednesday, September 01 2010 @ 02:52 PM CDT
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Microscopically, the lesions are composed of small ducts with two rows of epithelium scattered throughout a fibrous stroma. The tubular lumina may be filled with amorphous debris. Horn cysts are often present near the surface, while squamous metaplasia can be present throughout. Some of the ducts have characteristic comma-like tails and there are often solid strands of basophilic epithelial cells throughout the stroma which are independent of the ducts. These findings are similar to syringomas of the skin, which usually occur on the face and axilla, neck, vulva, and ventral torso. Syringomatous adenoma of the nipple differs from a syringoma of the skin in that there may be invasion of smooth muscle bundles and perineural invasion. Extension into the subcutaneous tissue and of parenchyma of the breast is common. There have been reports of similar skin lesion. This was first reported in 1982 by Goldstein et al and called microcystic adnexal carcinoma Other reports have designated it as sclerosing sweat duct (syringomatous) carcinoma, malignant syringoma, desmoplastic trichoepithelioma, and trichofolliculoma. This tumor shows both pilar and eccrine differentiation. In general, syringomatous tumor of the nipple lacks cytologic atypia, has minimal mitotic activity, and only rare foci of necrosis. It tends to recur unless completely excised. Recurrence has been reported up to 30 years later. In a few cases, the recurrences are slow growing, but distant metastasis has not been reported. Complete excision, not mastectomy, with long term follow-up is the treatment of choice.
Infiltrating syringomatous adenoma of the nipple
Wednesday, April 15 2009 @ 11:01 PM CDT
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Adenomyoepithelioma of the breast arises from myoepithelial and epithelial cells that are widely present in the normal breast lobules and ducts.
Tubular Adenomyoepithelioma
Saturday, August 02 2008 @ 05:15 PM CDT
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Note the marked pleomorphism of the cells with variation in size, shape and polarity. Signet ring cells are obvious as well as atypical mitosis and apoptosis.
Pleomorphic Lobular Carcinoma
Saturday, August 02 2008 @ 05:15 PM CDT
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Adenoma or florid papillomatosis of the nipple is a rare, benign neoplasm of breast lactiferous ducts , clinically frequently misdiagnosed as Paget's disease. Histologically this is a well- defined lesion in the nipple dermis composed of ducts similar to
Nipple Adenoma
Saturday, August 02 2008 @ 05:15 PM CDT
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Spindle cell carcinoma of the breast (SpCC) is characterized by a histology that shows a predominant spindle cell pattern. The spindle cells may be benign appearing, low-grade cells, or may have a high-grade, sarcomatoid appearance. Although ductal, lobul
Spindle Cell Carcinoma of the Breast
Saturday, August 02 2008 @ 05:15 PM CDT
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The carcinoma is unremarkable: ductal, lobular or both..a Multinucleated giant cells associated with the breast carcinoma: 3-50 nuclei Cytologically bland May have prominent nucleoli No mitotic activity in giant cells Usually located in stroma
Breast Carcinoma with Osteoclast-like Giant Cells
Saturday, August 02 2008 @ 05:15 PM CDT
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Adenolipoma is a sharply circumscribed mass of disordered breast ducts and lobules; Note that the ducts have 2 cell layers.
Adenolipoma of the Breast (Hamartoma)
Saturday, August 02 2008 @ 05:15 PM CDT
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Neurofibromatosis of the Breast
Wednesday, November 16 2005 @ 02:54 PM CST
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Adenoid cystic carcinoma of the breast is character-ized mainly by small basaloid cells either with solid,cribriform or tubular growth patterns which are fre-quently mixed although anyone may predominate. De-spite its characteristic histology, adenoid cys
Adenoid Cystic Carcinoma of the Breast
Saturday, August 02 2008 @ 05:15 PM CDT
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Sir James Paget first described Paget disease (PD) of the breast in 1874. He reported a chronic eczematous disease on the skin of the nipple and the areola in 15 women, with an associated intraductal carcinoma of the underlying mammary gland. The epidermi
Pagets Disease Of The Nipple
Saturday, August 02 2008 @ 05:14 PM CDT
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monomorphic cell population, which distends and distorts the lobules oval/round nuclei with prominent nucleoli signet ring cells (not pictured) Shown also is a central area of necrosis which might misslead the pahologist to think that this is actu
Lobular Carcinoma in situ (LCIS)
Saturday, August 02 2008 @ 05:14 PM CDT
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