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Friday, May 24 2013 @ 09:04 AM CDT

Soft tissues
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Benign tumor. To make this diagnosis the following 2 criteria must be met: A) Adipocitic component - composed of mature adipocites. B) Myeloid component - composed of all 3 lineages, ertithroid islands, myeloid precursors and megacariocytes. DDX: Myeloid sarcoma (CD34+) blasts only infiltrating the fat.
Myelolipoma
Tuesday, January 22 2013 @ 07:45 AM CST
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Affects the knee joints and it is a neoplastic process closely related to tenosynovial giant cell tumor. it can be focal and diffuse.
Pigmented Villonodular Synovitis (PVNS)
Thursday, October 04 2012 @ 10:45 AM CDT
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This is slow growing cellular tumor composed of mononuclear cells with with eosinophilic cytoplasm and grooved nuclei. Occasional osteoclast-like giant cells may be seen. The biologic potential of this tumor can not be predicted based on cellular criteria of malignancy. Benign pulmonary metastasis have been described.
Chondroblastoma
Wednesday, August 15 2012 @ 11:40 AM CDT
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Sclerosing mesenteritis is part of a spectrum (including mesenteric lipodystrophy and mesenteric panniculitis) of idiopathic primary inflammatory and fibrotic processes that affect the mesentery. The main differential is: inflammatory myofibroblastic tumor, well-differentiate liposarcoma-sclerosing variant and Desmoid tumor. This lesion shows that the spindle cells are: SMA positive and negative for S-100, Desmin, Keratin and CD117.
Sclerosing Mesenteritis
Monday, March 19 2012 @ 10:43 AM CDT
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This group of tumors include: angiomyolipoma, lymphangioleiomyomatosis and clear cell "sugar" tumor of lung. Immunohistochemically they all express myogenous and melanocitic markers: SMA, HMB-45 and Melan-A , Desmin in about 50%.
Malignant Perivascular Epithelioid Tumor (PEComa)
Monday, March 19 2012 @ 10:31 AM CDT
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Benign, usually self-limited, proliferative disorder of dendrocytes in skin demonstrating dense dermal infiltrate of lymphocytes, histiocytes, Touton giant cells (usually), eosinophils and neutrophils, which may extend into subcutis.
Juvenile Xanthogranuloma
Tuesday, December 27 2011 @ 12:07 PM CST
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Pathognomonic for neurofibromatosis type 1 (von Recklinghausen disease)
Plexiform Neurofibroma
Wednesday, July 20 2011 @ 10:46 AM CDT
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KHE lesions are rare locally aggressive vascular tumors of the skin, deep soft tissue and bone in children. They commonly are found in the upper trunk and extremities, thigh, sacrum or retro peritoneum. They usually are present at birth but can appear shortly after birth. They affect both sexes equally. The majority of KHE lesions are associated with Kasabach-Merritt phenomenon but there are reports of patients with these lesions that do not have this phenomenon. Tumour consists of infiltrating lobulated nodules of spindle shaped endothelial cells separated by fibrous bands ; Spindle cells form short fascicles and line slit-like and round vessels ; There is minimal cytological atypia with low mitotic activity.
Kaposiform Hemangioendothelioma
Tuesday, June 21 2011 @ 08:32 AM CDT
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Hard diagnosis since it resembles fibrous dysplasia. Generally mild nuclear atypia with occasional mitotic figures and periosteal destruction and extension into the soft tissues. If you face such case I strongly suggest you send it out to a specialist for a second opinion or review it on a interdepartmental consensus conference.
Low-grade Intraosseus Osteosarcoma
Thursday, March 17 2011 @ 10:14 AM CDT
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Neoplasm which is composed of smooth muscle cells derived from the glomus body. It can appear anywhere but usually on distal extremities. The cells are positive for SMA and Vim. Desmin and S-100 are usually negative. It is part of the Blue ANGEL mnemonic: Blue rubber bleb nevus, Angiolipoma, Neuroma, Glomus tumor, Eccrine spiradenoma, Leiomyoma
Glomus Tumor
Thursday, March 17 2011 @ 10:13 AM CDT
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Benign lesion usually in females who had some history of abdominal trauma. The cells are positive for CK5/6 Ck-7 Calretinin and D2-40. Some people believe its reactive process while others believe that is neoplastic.
Multicystic Peritoneal Mesothelioma
Thursday, March 17 2011 @ 10:13 AM CDT
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Fibroblastic tumor of children and young adults, usually localized in the hands and wrists, with a significant tendency to recur locally.The tumor is composed of spindled fibroblasts with a fascicular growth pattern and scattered epithelioid cells bordering chondroid foci with or without mineralization. The plump spindle cells contain round or ovoid nuclei and indistinctly outlined cytoplasm. There is a linear or palisading arrangement specially around calcified material. Some of these cells resemble chondrocytes.
Calcifying Aponeurotic Fibroma
Tuesday, January 25 2011 @ 11:16 AM CST
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