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Wednesday, April 16 2014 @ 10:57 PM CDT
Soft tissues
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Angiolymphoid hyperplasia with eosinophilia also known as epithelioid hemangioma is a distinctive vascular lesion which usually occurs during early and mid adult life (20- 40 years).Microscopically, these are well circumscribed lesions usually located in the dermis and subcutis. Angiolymphoid hyperplasia with eosinophilia consists of vascular and inflammatory cellular components.The vascular component displays thick and thin walled vessels lined by plump endothelial cells. The epithelioid endothelial cells have rounded nuclei abundant eosinophilic cytoplasm containing occasional vacuoles that represent primitive vascular lumen formation. These endothelial cell protrude into the vessels in a 'tombstone' pattern. Within some thicker vessels there is intravascular proliferations of the endothelial cells.

Differential diagnosis
Kimura disease
epithelioid hemangioendothelioma
epithelioid angiosarcoma


- CD31 +
- factor VIIIrAg +
- CD34 +

- +/- keratins
- +/- focal muscle-specific actin-positive myopericytic cells

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Saturday, August 02 2008 @ 04:38 PM CDT
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