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Sunday, October 26 2014 @ 01:49 AM UTC

Breast
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the following crirteria should be applied: Large cells with abundant granular eosinophilic cytoplasm, nucleus to cytoplasm ratio of 1:2 or more, nuclei round, large and vesicular and may have a prominent cherry red nucleolus with sharply defined cell borders
Immuno: GCFDP-15 and Androgen receptor positive

DDX:
Oncocytic carcinoma - GCDFP-15 negative
Hystiocytoid carcinoma- weakly eosinophilic cytoplasm and amphophilic cytoplasm
Secretory carcinoma- dPAS positive for mucin, young age

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Tuesday, February 01 2011 @ 03:29 PM UTC
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Authored by: interstitial lung disease on Monday, February 06 2012 @ 07:42 AM UTC Apocrine Carcinoma of Breast
Large cells with abundant granular eosinophilic cytoplasm, nucleus to interstitial lung disease cytoplasm ratio of 1:2 or more, nuclei round, large and vesicular and may have a prominent cherry red nucleolus with sharply defined cell borders Immuno: GCFDP-15 and Androgen receptor positive
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By gross actualization apocrine breast tumors are about duplicate from added invasive breast carcinomas. When advised by a microscope apocrine breast tumors usually arise as sheets, cords, and sometimes tubules of neoplastic cells. The a lot of accessible cytological appearance of apocrine blight are ample amounts of eosinophilic, diminutive cytoplasm ( absolute particles or grains, which stain added easily), bump beef with categorical margins, and ample vesicular nuclei which are generally annular or oval. The basis to cytoplasm arrangement is about 1:2. Apocrine carconima beef frequently acknowledge 'apocrine snouts'. These 'snouts' are in fact accumulations of buried granules in the aciculate cytoplasm ( the cytoplasm about the top or free-end of the cell, spilling into the lumen of the breast ducts), that is acutely appear by staining dyes. Windows 8
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