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Pediatric Pathology
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Biphasic pattern of cytotrophoblast alternating with sheets of syncytiotrophoblast. These cells show nuclear atypia and prominent cytoplasmic vacuoles. Mitotic figures are frequent. Extensive areas of hemorrhage and necrosis are present. The syncytiotrophoblast stain intensely for human chorionic gonadotropin and weakly for human placental lactogen with immunohistochemistry. Cytotrophoblast do not stain with either.

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Thursday, April 23 2009 @ 06:10 PM UTC
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